Radiation Oncology/NHL/Lymphoblastic

Front Page: Radiation Oncology | RTOG Trials | Randomized Trials

Non-Hodgkin lymphoma: Main Page | Randomized
Overview: Overview | Follicular | Diffuse large B-cell | MALT | Nodal marginal zone | Mantle cell | CLL/SLL | Lymphoblastic | Burkitt | NK/T cell | Anaplastic large cell | Primary CNS Lymphoma
Treatment: Aggressive | Specific sites | Radioimmunotherapy

  • Can present either as Acute Lymphoblastic Leukemia (ALL) or as lymphoblastic lymphoma (LBL)
  • Lymphoblastic lymphoma seen more commonly in children and adolescents -- account for 1/2 of pediatric lymphomas.
  • May spread to gonads or CNS "sanctuary sites.
  • Can be either T-cell precursor or B-cell precursor:
  • Precursor B-cell
    • Most commonly presents as ALL, rarely as LBL
    • Commonly bone marrow failure; clinical signs pallor, fatigue, bleeding, fever, infection; labs cytopenias
    • Extranodal sites commonly involved (hepatomegaly, splenomegaly, CNS disease, testicular enlargement, cutaneous infiltration)
    • Adverse features: very high WBC, symptomatic CNS disease, unfavorable cytogenic abnormalities (eg t(9;22))
  • Precursor T-cell:
    • Commonly high WBC counts, mediastinal mass, lymphadenopathy, hepatosplenomegaly
    • Can present with bone marrow failure, although typically less severe than precursor B-cell ALL/LBL
    • Common presentation is young men with mediastinal mass/pleural effusions
    • CNS involvement common