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Radiation Oncology/Toxicity/Brainstem

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Brain Stem Toxicity


Nausea

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  • Higher nausea and vomiting if mean brainstem dose >36 Gy


  • MD Anderson; 2008 PMID 18455324 -- "Beam Path Toxicities to Non-Target Structures During Intensity-Modulated Radiation Therapy for Head And Neck Cancer." (Rosenthal DI, Int J Radiat Oncol Biol Phys. 2008 May 1. [Epub ahead of print])
    • Retrospective. 160 patients, oropharynx, treated with IMRT and 3D-CRT
    • Nausea: Higher nausea and vomiting if mean brainstem dose >36 Gy.
    • Occipital alopecial: if occipital scalp dose >30 Gy
    • Anterior mucositis: if anterior mandible dose >34 Gy
    • Conclusion: Dose reduction during IMRT implies increased beam path dose to alternate structure that may result in toxicities uncommon with previous approaches
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