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Radiation Oncology/RTOG Trials/7605

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RTOG 76-05 (LIVER)

  • Title: Pilot Study of Radiotherapy for Palliation of Symptomatic Hepatic Metastases
  • Objective:
    • I. Evaluate the frequency and duration of symptom relief, frequency and duration of normalization of (a) liver tests and (b) of abnormal liver scans, as a function of dose schedules, varying fraction size and overall time.
    • II. Evaluate the above responses according to site and histopathology of the primary.
    • III. Evaluate the above objectives with respect to survival times.
    • IV. Evaluate, via histopathologic correlation, the frequency of radiation hepatitis as a function of dose schedule and concomitant chemotherapy.
  • Protocol: RT for patients with solitary vs. multiple mets
  • Eligibility: hepatic metastases documented by liver scan
  • Enrolled:
  • Conclusion:
    • PMID 6168623 -- The palliation of hepatic metastases: results of the Radiation Therapy Oncology Group pilot study. (1981 Borgelt BB, Int J Radiat Oncol Biol Phys. 1981 May;7(5):587-91.)
  • Publications:
    • PMID 2180867 -- Accelerated fractionation radiation therapy for liver metastases: selection of an optimal patient population for the evaluation of late hepatic injury in RTOG studies. (1990 Leibel SA, Int J Radiat Oncol Biol Phys. 1990 Mar;18(3):523-8.)
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