Radiation Oncology/RTOG Trials/0321

RTOG 03-21 (PROSTATE)

• Title: Phase II Trial of Combined High Dose Rate Brachytherapy and External Beam Radiotherapy for Adenocarcinoma of the Prostate
• Objective: To estimate the rate of late Grade 3 or greater genitourinary and gastrointestinal toxicity following treatment with external beam radiation therapy and high dose rate brachytherapy
• Protocol: 45 Gy EBRT (no IMRT) + 19 Gy (2 fractions) HDR boost
• Eligibility:
  • (cT1c-T2c and GS 2-6 and PSA 10-20) or
  • (cT3a-T3b and GS 2-6 and PSA <=20) or
  • (T1c-T3b and GS 7-10 and PSA <=20)
  • N0M0
• Enrollment Target: 110 patients
• Activation: July 30, 2004