Radiation Oncology/Physics/Dose evaluation

Dose Evaluation

• Bragg-Gray cavity theory
  • Radiation dose in a cavity volume of material to the dose that would exist in a surrounding medium in the absence of the cavity volume
• Spencer-Attix Cavity Theory
  • Hugo Bouchard. Phys Med Biol. 2012. A theoretical re-examination of Spencer-Attix cavity theory (PMID: 22572534)

• Duke; 2006 PMID 17056197 -- "Dosimetric feasibility of cone-beam CT-based treatment planning compared to CT-based treatment planning." (Yoo S, Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1553-61.)
  • Conclusion: CBCT treatment planning is feasible; dosimetry comparable to CT-based plans

• UCSF; 2005 PMID 15936579 -- "Method to account for dose fractionation in analysis of IMRT plans: modified equivalent uniform dose." (Park CS, Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3):925-32.)
  • Modified equivalent uniform dose (mEUD) that accounts for dose fractionation using biologically effective dose for use in IMRT plans

• Colorado; 2003 PMID 12674231 -- "How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?" (Kavanagh BD, Med Phys. 2003 Mar;30(3):321-4.)
  • EUD appears more robust, TCP more valuable for post-hoc estimation

• Harvard; 1997 PMID 9029544 -- "Reporting and analyzing dose distributions: a concept of equivalent uniform dose." (Niemierko A, Med Phys. 1997 Jan;24(1):103-10.)