Radiation Oncology/Colon/NSABP trials

The National Surgical Adjuvant Breast and Bowel Project (NSABP):

See other NSABP trials and NSABP Rectal trials
See the NSABP web page.

• C-01 - Dukes B and C, randomized after curative resection to no further treatment, vs. 5-FU + semustine + vincristine (MOF), vs. BCG (1977-83)
  • PMID 3276901 (1988), 10 year results: PMID 15292384 (2004)

• C-03 (1987-89) - Resected Stage II-III colon ca, 5-FU/LV vs MOF(semustine, vincristine, and 5-FU)
  • PMID 8410113 (1993)
  • 10-year results (2005): O'Connell MJ et al. J Clin Oncol (Meeting Abstracts) 2005 23: 3511.

• C-04 (1989-90) - Stage II-III. 5-FU/levamisole(LEV) vs 5-FU/LV vs 5-FU/LV/LEV.
  • PMID 10550154 (1999)

• C-06 (1997-99) - Resected Stage II-III colon ca, 5-FU/LV vs oral uracil/tegafur (UFT). Equivalence trial.
  • PMID 16648506 (2006)
  • PMID 17264338 (2007) - quality of life