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Radiation Oncology/Brachytherapy/General concepts

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Manchester system

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(also called Patterson-Parker)

  • Dose and dose rate: 6000 R - 8000 R in 6-8 days (1000 R/d, 40 R/h)
  • Dose specification criterion: Effective minimum dose is 10% above the minimum dose in treatment plane or volume
  • Dose gradient: Dose in treatment volume or plane varies by no more than 10% from stated dose except for localized hot spots
  • Linear activity: 0.66 and 0.33 mgRaEq/cm


HDR Fractionation

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  • Amsterdam; 2002 PMID 11849810 -- "The optimal fraction size in high-dose-rate brachytherapy: dependency on tissue repair kinetics and low-dose rate." (Sminia P, Int J Radiat Oncol Biol Phys. 2002 Mar 1;52(3):844-9.)
    • Evaluation of optimal fraction size in HDR brachytherapy; assume 20 Gy in either LDR or HDR, repair half-life 1-4 hours and 3x longer than tumor
    • Optimal fractionation: 3 x 6.7 Gy or 4 x 5 Gy


For HDR vs LDR BED calculator, see:

Electronic brachytherapy

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  • ASTRO; 2010 PMID 20206016 -- "American Society for Therapeutic Radiology and Oncology (ASTRO) Emerging Technology Committee report on electronic brachytherapy." (Park CC, Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):963-72.)


GEC ESTRO Handbook

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