Radiation Oncology/Brachytherapy/General concepts

Manchester system Edit
(also called PattersonParker)
 Dose and dose rate: 6000 R  8000 R in 68 days (1000 R/d, 40 R/h)
 Dose specification criterion: Effective minimum dose is 10% above the minimum dose in treatment plane or volume
 Dose gradient: Dose in treatment volume or plane varies by no more than 10% from stated dose except for localized hot spots
 Linear activity: 0.66 and 0.33 mgRaEq/cm
HDR Fractionation Edit
 Amsterdam; 2002 PMID 11849810  "The optimal fraction size in highdoserate brachytherapy: dependency on tissue repair kinetics and lowdose rate." (Sminia P, Int J Radiat Oncol Biol Phys. 2002 Mar 1;52(3):8449.)
 Evaluation of optimal fraction size in HDR brachytherapy; assume 20 Gy in either LDR or HDR, repair halflife 14 hours and 3x longer than tumor
 Optimal fractionation: 3 x 6.7 Gy or 4 x 5 Gy
For HDR vs LDR BED calculator, see:
Electronic brachytherapy Edit
 ASTRO; 2010 PMID 20206016  "American Society for Therapeutic Radiology and Oncology (ASTRO) Emerging Technology Committee report on electronic brachytherapy." (Park CC, Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):96372.)