Radiation Oncology/Bone/Background

Epidemiology

Incidence: 8 per 1,000,000.
2440 cases in 2004.

Incidence: osteosarcoma (35%), chondrosarcoma (30%), Ewing's sarcoma (16%)

Histology

Histologic Origin	Proportion	Malignant Tumor
Hematopoietic	41%	Myeloma
Chondrogenic	21%	Chondrosarcoma
Osteogenic	19%	Osteosarcoma
Unknown/bone marrow	10%	Ewing's tumor Malignant giant cell tumor Adamantinoma
Fibrogenic	4%	Fibrosarcoma
Notochordal	3%	Chordoma
Vascular	2%	Hemangioendothelioma Hemangiopericytoma

Note: Adapted from Dahlin DC, Bone tumors: general aspects and data on 6,221 cases, 3rd ed. 1978

Location

• EG-MODE
  • Epiphysis: Giant cell
  • Metaphysis: Osteosarcoma
  • Diaphysis: Ewing's sarcoma