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Biomedical Engineering Theory And Practice/Biomaterials

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Biomedical Engineering Theory And Practice
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Introduction edit

The United States National Institute of Health Consensus Development Conference defined a biomaterial as ‘‘Any substance (other than a drug) or combination of substances, synthetic or natural in origin, which can be used for any period of time, as a whole or as a part of a system which treats, augments, or replaces any tissue, organ, or function of the body’’ (Boretos and Eden, 1984)[1]. Biomaterials area has grown over for 50 years. Biomaterils as a field uses ideas from medicine, biology, chemistry, materials science and engineering. In addition, biomaterials researchers should consider ethics,law and the health care delivery system.

Biomaterials can be divided into metals, ceramics, polymers, glasses, carbons, and composite materials. Table 1 shows a few applications for synthetic materials in the body. It contains many materials that are often classified as “biomaterials.” Metals, ceramics, polymers, glasses, carbons, and composite materials are listed in this table. Such materials are used as molded or machined parts, coatings, fibers, films, foams,fabrics, liquid and powder. Table 2 presents the size of the commercial market for biomaterials and medical devices.The global biomaterial market would reach $88.4 billion by 2017 from $44.0 billion in 2012. The biomaterial market grows continually and globally because of increased investiments, funding and grant by government, active collaboration, technology advancement, increasing application of biomaterials and growing number of elderly people[2].


Table 1. Types of Biomaterials, characteristics and applications[3][4][5]Invalid parameter in <ref> tag[6]

Material Advantages Disadvantages Main Applications
Polymers: Silastic, Teflon, Dacron, Nylon, PMMA, Polyethylene, Polypropylene, Polytetrefluorethylene Easy to produce, low density Low mechanical resistance, easily degradable Sutures, arteries, veins, cements, artificial tendons, teeth, ears, nose, heart valves, lenses, testicles and breasts. implants
Metals: Steels 316, 316L, Vitallium, Silver, Tantalum Cobalt F-75 and alloys of: Ti, Cr+CO, Cr+Co+Mo Ductility, high mechanical resistance to wear and shock Low biocompatibility, corrosion in a physiological environment, mechanical properties very different from those of biological tissues Staples, plaques and wires, articulation prosthesis, tooth implants, penis implants, skull plaques and mesh for face reconstruction
Ceramics: Aluminum oxides, calcium aluminates, titanium oxides, calcium phosphates, carbon, Bioglass High biocompatibility, corrosion resistance, high resistance to compression, inert, low thermal and electrical conductivity Low impact resistance, properties difficult to reproduce, difficulties in processing and fabrication Dental parts, coatings, bone fillings, endoscopy, otologic implants, medical tools and equipment
Composites: Metals with ceramic coatings, materials coated with carbon High biocompatibility, corrosion resistant, inert Lack of consistency and difficult to reproduce during fabrication Heart valves, knee implants, artificial articulations, hip implants
Natural Materials: Collagen, human tissues, hialuronic acid, grafts Availability in the human body, biocompatibility Possible rejection by host Increase or substitution of hard and soft tissues, cornea protectors, vascular grafts, tendons and ligaments, heart valves, phthalmologic lubricants, substitution of synovial fluid

Table 2. Biomaterials and Healthcare market

Total US health expenditures $2.9 trillion (2013)[7]
Total U.S. medical device market $110 billion(2014)[8]
The global market for biomaterials $44.0 billion(2012)[2]

Further Reading edit

  • Bronzino, Joseph D. (April 2006). The Biomedical Engineering Handbook, Third Edition. [CRC Press]. ISBN 978-0-8493-2124-5.
  • Villafane, Carlos, CBET. (June 2009). Biomed: From the Student's Perspective, First Edition. [Techniciansfriend.com]. ISBN 978-1-61539-663-4.{{cite book}}: CS1 maint: multiple names: authors list (link)
  • Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. (November 8, 2012). Biomaterials Science: An Introduction to Materials in Medicine. Academic Press. ISBN 978-0123746269.{{cite book}}: CS1 maint: multiple names: authors list (link)

Practise edit

Reference edit

  1. ↑ Boretos, J.W., Eden, M. Contemporary Biomaterials, Material and Host Response, Clinical Applications, New Technology and Legal Aspects. Noyes Publications, Park Ridge, NJ (1984), pp. 232–233.
  2. ↑ a b Custom Market Research Services,Biomaterials
  3. ↑ Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. (November 8, 2012). Biomaterials Science: An Introduction to Materials in Medicine. Academic Press. p. 2. ISBN 978-0123746269.{{cite book}}: CS1 maint: multiple names: authors list (link)
  4. ↑ J. B. Park, Biomaterials Science and Engineering, Plenum Press, New York,1984.
  5. ↑ K. Mattox, Biomaterials- Hard Tissue Repair and Replacement, vol. 3 (D. Muster,Editor), Elsevier, Amsterdam, 1992.
  6. ↑ Alejandro Sáenz, Eric Rivera-Muñoz, Witold Brostow and Victor M. Castaño,CERAMIC BIOMATERIALS: AN INTRODUCTORY OVERVIEW, Journal of Materials Education Vol.21 (5-6): 297 - 306 (1999)
  7. ↑ Centers for Disease Control and Prevention
  8. ↑ SELECTUSA,The Medical Device Industry in the United States

A Brief review: Biomaterials and their application, Amogh Tathe et al,Int J Pharm Pharm Sci, Vol 2, Suppl 4, 19­23


Biomaterials by Joon B. Park, Roderic S. Lakes

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