Hyperprolactinaemia, or excess serum prolactin, is associated with hypoestrogenism, anovulatory infertility, oligomenorrhoea, amenorrhoea, unexpected lactation, and loss of libido in women, and erectile dysfunction and loss of libido in men.[1]
1. Physiological
- Coitus
- Exercise
- Lactation
- Pregnancy
- Sleep
- Stress
- Anesthetics
- Anticonvulsant
- Antihistamines (H2)
- Antihypertensives
- Cholinergic agonist
- Drug-induced hypersecretion
- Catecholamine depletor
- Dopamine receptor blockers
- Dopamine synthesis inhibitor
- Estrogens
- Oral contraceptives
- Oral contraceptive withdrawal
- Neuroleptics
- Antipsychotics
- Neuropeptides
- Opiates and opiate antagonists
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3. Pathological
- Hypothalamic-pituitary stalk damage
- Granulomas
- Infiltrations
- Irradiation
- Rathke's cyst
- Trauma
- Pituitary stalk resection
- Suprasellar surgery
- Tumors
- Craniopharyngioma
- Germinoma
- Hypothalamic metastases
- Meningioma
- Suprasellar pituitary mass extension
- Surgery
- Pituitary
- Acromegaly
- Idiopathic
- Lymphocytic hypophysitis or parasellar mass
- Macroadenoma (compressive)
- Macroprolactinemia
- Plurihumoral adenoma
- Prolactinoma
- Systemic disorders
- Chest-neurologic chest wall trauma
- Herpes Zoster
- Chronic renal failure
- Cirrhosis
- Cranial radiation
- Epileptic seizures
- Polycystic ovarian disease
- Pseudocyesis
- Chronic low levels of thyroid hormone
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- ↑ Melmed S, Kleinberg D 2008 Anterior pituitary. 1n: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Willams textbook of endocrinology. 11th ed. Philadelphia: Saunders Elsevier; 185-261