Surgical oncology is a subspecialty within general surgery accredited by the Accreditation Council for Graduate Medical Education that focuses on the surgical management of breast, head and neck, skin and soft tissue, gastrointestinal, hepatopancreaticobiliary, and colorectal cancers.
The primary aim of this text is to provide brief summaries of key clinical trials most relevant to surgical oncology trainees in each of these areas.
Surgical management of primary tumorEdit
NSABP B-04: Randomized trial of radical mastectomy, total mastectomy, vs total mastectomy + XRTEdit
Breast cancer patients with clinically negative axillary nodes were randomized to radical mastectomy, total mastectomy without axillary dissection but with postoperative irradiation, or total mastectomy plus axillary dissection only if their nodes became positive. There were no significant differences in disease-free survival or overall survival. Additionally, women with clinical positive nodes who underwent total mastectomy did not show a survival benefit from adjuvant radiation.
NSABP B-06: Randomized trial of breast conserving surgery versus mastectomyEdit
Women with tumors 4cm or smaller were randomized to lumpectomy and axillary lymph node dissection with or without breast radiation (50 Gy) or modified radical mastectomy. There were no significant differences between the groups in disease-free survival or overall survival. However, ipsilateral recurrences were decreased with the addition of breast radiation to lumpectomy compared to lumpectomy alone.
Surgical management of axillaEdit
Adjuvant hormonal therapyEdit
Neoadjuvant chemotherapy, chemoradiation, or radiationEdit
Patients with high-grade sarcoma ≥8 cm received neoadjuvant MAID chemotherapy (mesna, doxorubicin, ifosfamide, and dacarbazine) and radiation, plus postoperative MAID. Toxicity was significant, but survival was better than anticipated.
Sarcoma Meta-Analysis CollaborationEdit
Data from 14 trials showed increased times to local and distant recurrence and higher recurrence free survival with doxorubicin-based chemotherapy in patients with localized, resectable extremity sarcomas. There was a nonsignificant trend towards increased overall survival.
Italian Randomized Cooperative Trial: Adjuvant chemotherapy vs. observationEdit
Patients with high-grade or recurrent extremity sarcoma were randomized to receive adjuvant chemotherapy with epirubicin + ifosfamide vs. observation alone. Chemotherapy was associated with significant improvements in disease free survival and there was a nonsignificnat trend towards improved 5-year overall survival.
Patients with resected sarcomas were randomized to receive adjuvant chemotherapy with ifosfamide + doxorubicin + lenograstim vs. observation alone. There were no benefits in relapse-free survival or overall survival.
Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial: Perioperative ECF vs surgery aloneEdit
Patients with resectable adenocarcinoma of stomach, GE junction, or lower esophagus were randomized to perioperative chemotherapy (3 cycles ECF pre-op, 3 cycles ECF post-op) + surgery vs. surgery alone. There were no differences in perioperative morbidity and mortality. Tumors were smaller and less advanced with perioperative chemotherapy. The perioperative chemotherapy group had significantly improved progression free survival and overall survival.
Macdonald trial: Perioperative chemoradiation vs surgery aloneEdit
Patients with resected adenocarcinoma of the stomach or GE junction were randomized to surgery + postoperative chemoradiation (5-FU + leucovorin + 45 Gy) vs. surgery alone. The postoperative chemoradiation group had significant longer overall survival and lower relapse rates. Of note, most patients had D0/D1 lymphadenectomy.
Adjuvant Chemoradiation Therapy in Stomach Cancer (ARTIST) trial: Adjuvant chemotherapy vs. adjuvant chemoradiationEdit
Patients with resected gastric cancers with D2 lymph node dissection were randomized to postoperative treatment with capecitabine plus cisplatin versus cisplastin plus radiotherapy with capecitabine. Adding radiation to chemotherapy did not significantly lower recurrence rates.
GASTROINTESTINAL STROMAL TUMORSEdit
Neoadjuvant + adjuvant targeted therapyEdit
RTOG 0132: Phase II study of neoadjuvant/adjuvant imatinibEdit
First study that evaluated neoadjuvant + adjuvant imatinib for resectable GIST prospectively. Demonstrated acceptable survival as well as high rates of disease progression after discontinuation of maintenance therapy.
EORTC STBSG pooled analysisEdit
Pooled data from 10 sarcoma centers. Patients with locally advanced, nonmetastatic GISTs who were treated upfront with neoadjuvant imatinib went on to have an 83% rate of R0 resections. About half of the patients also had adjuvant imatinib.
Adjuvant targeted therapyEdit
ACOSOG Z9000: Phase II study of adjuvant imatinibEdit
106 patients who had complete resections but at high risk for recurrence were given imatinib 400 mg daily x 1 year and followed with serial radiologic evaluation. The 5-year OS rate was 83% compared to historical 5-year OS rate of 35%. Recurrence free survival was lower with large tumor size, small bowel primary, KIT exon 9 mutation, high mitotic rate, and older age.
ACOSOG Z9001: Phase III trial of adjuvant imatinibEdit
Patients who had complete resections of cKIT+ GIST ≥ 3 cm were randomized to imatinib 400 mg or to placebo daily x 1 year after surgical resection. Imatinib significantly improved recurrence-free survival compared with placebo and was well tolerated.
Patients with resected cKIT+ GIST with high risk of recurrence were randomized to imatinib, 400 mg daily, x 12 months vs. 36 months. Those in the 36 month group had significantly longer 5-year RFS (65.6% vs 47.9%) and longer 5-year overall survival (92.0% vs 81.7%).
Targeted therapy for advanced diseaseEdit
B2222 study: Safety of imatinib in advanced GISTEdit
Imatinib associated with disease control in patients with advanced GIST. Low tumor burden was associated with improved overall survival.
Randomized patients with metastatic or unresectable GIST to 400mg daily vs. 800mg daily. Overall survival was equivalent but there were more side effects with the higher dose. However, progression free survival was longer in patients on higher dose.
Similar to EORTC 62005. Randomized patients with metastatic or unresectable GIST to 400mg daily vs. 800mg daily. Overall survival was equivalent but there were more side effects with the higher dose. However, no difference in progression free survival was seen.
Targeted therapy for advanced diseaseEdit
SHARP Investigators / Llovet et al: Sorafenib for advanced diseaseEdit
Patients with advanced HCC randomized to receive either sorafenib or placebo. Median overall survival was significantly longer in the sorafenib group.
- Fisher, Bernard; Jeong, Jong-Hyeon; Anderson, Stewart; Bryant, John; Fisher, Edwin R.; Wolmark, Norman (2002). "Twenty-Five-Year Follow-up of a Randomized Trial Comparing Radical Mastectomy, Total Mastectomy, and Total Mastectomy Followed by Irradiation". New England Journal of Medicine 347 (8): 567–75. doi:10.1056/NEJMoa020128. PMID 12192016.
- Fisher, Bernard; Anderson, Stewart; Bryant, John; Margolese, Richard G.; Deutsch, Melvin; Fisher, Edwin R.; Jeong, Jong-Hyeon; Wolmark, Norman (2002). "Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer". New England Journal of Medicine 347 (16): 1233–41. doi:10.1056/NEJMoa022152. PMID 12393820.
- Kraybill, William G.; Harris, Jonathan; Spiro, Ira J.; Ettinger, David S.; Delaney, Thomas F.; Blum, Ronald H.; Lucas, David R.; Harmon, David C. et al. (2010). "Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall". Cancer 116 (19): 4613–21. doi:10.1002/cncr.25350. PMID 20572040.
- "Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: Meta-analysis of individual data". The Lancet 350 (9092): 1647–54. 1997. doi:10.1016/S0140-6736(97)08165-8. PMID 9400508.
- Frustaci, Sergio; Gherlinzoni, Franco; De Paoli, Antonino; Bonetti, Marco; Azzarelli, Alberto; Comandone, Alessandro; Olmi, Patrizia; Buonadonna, Angela et al. (2001). "Adjuvant Chemotherapy for Adult Soft Tissue Sarcomas of the Extremities and Girdles: Results of the Italian Randomized Cooperative Trial". Journal of Clinical Oncology 19 (5): 1238–47. doi:10.1200/JCO.2001.19.5.1238. PMID 11230464.
- Woll, Penella J; Reichardt, Peter; Le Cesne, Axel; Bonvalot, Sylvie; Azzarelli, Alberto; Hoekstra, Harald J; Leahy, Michael; Van Coevorden, Frits et al. (2012). "Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): A multicentre randomised controlled trial". The Lancet Oncology 13 (10): 1045–54. doi:10.1016/S1470-2045(12)70346-7. PMID 22954508.
- Cunningham, David; Allum, William H.; Stenning, Sally P.; Thompson, Jeremy N.; Van De Velde, Cornelis J.H.; Nicolson, Marianne; Scarffe, J. Howard; Lofts, Fiona J. et al. (2006). "Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer". New England Journal of Medicine 355 (1): 11–20. doi:10.1056/NEJMoa055531. PMID 16822992.
- MacDonald, John S.; Smalley, Stephen R.; Benedetti, Jacqueline; Hundahl, Scott A.; Estes, Norman C.; Stemmermann, Grant N.; Haller, Daniel G.; Ajani, Jaffer A. et al. (2001). "Chemoradiotherapy after Surgery Compared with Surgery Alone for Adenocarcinoma of the Stomach or Gastroesophageal Junction". New England Journal of Medicine 345 (10): 725–30. doi:10.1056/NEJMoa010187. PMID 11547741.
- Lee, Jeeyun; Lim, Do Hoon; Kim, Sung; Park, Se Hoon; Park, Joon Oh; Park, Young Suk; Lim, Ho Yeong; Choi, Min Gew et al. (2012). "Phase III Trial Comparing Capecitabine Plus Cisplatin Versus Capecitabine Plus Cisplatin with Concurrent Capecitabine Radiotherapy in Completely Resected Gastric Cancer with D2 Lymph Node Dissection: The ARTIST Trial". Journal of Clinical Oncology 30 (3): 268–73. doi:10.1200/JCO.2011.39.1953. PMID 22184384.
- Wang, Dian; Zhang, Qiang; Blanke, Charles D.; Demetri, George D.; Heinrich, Michael C.; Watson, James C.; Hoffman, John P.; Okuno, Scott et al. (2011). "Phase II Trial of Neoadjuvant/adjuvant Imatinib Mesylate for Advanced Primary and Metastatic/recurrent Operable Gastrointestinal Stromal Tumors: Long-term Follow-up Results of Radiation Therapy Oncology Group 0132". Annals of Surgical Oncology 19 (4): 1074–80. doi:10.1245/s10434-011-2190-5. PMID 22203182.
- Rutkowski, Piotr; Gronchi, Alessandro; Hohenberger, Peter; Bonvalot, Sylvie; Schöffski, Patrick; Bauer, Sebastian; Fumagalli, Elena; Nyckowski, Pawel et al. (2013). "Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GIST): The EORTC STBSG Experience". Annals of Surgical Oncology 20 (9): 2937–43. doi:10.1245/s10434-013-3013-7. PMID 23760587.
- Dematteo, Ronald P.; Ballman, Karla V.; Antonescu, Cristina R.; Corless, Christopher; Kolesnikova, Violetta; von Mehren, Margaret; McCarter, Martin D.; Norton, Jeffrey et al. (2013). "Long-term Results of Adjuvant Imatinib Mesylate in Localized, High-Risk, Primary Gastrointestinal Stromal Tumor". Annals of Surgery 258 (3): 422–9. doi:10.1097/SLA.0b013e3182a15eb7. PMID 23860199.
- Dematteo, Ronald P; Ballman, Karla V; Antonescu, Cristina R; Maki, Robert G; Pisters, Peter WT; Demetri, George D; Blackstein, Martin E; Blanke, Charles D et al. (2009). "Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial". The Lancet 373 (9669): 1097–104. doi:10.1016/S0140-6736(09)60500-6. PMID 19303137.
- Joensuu, Heikki; Eriksson, Mikael; Sundby Hall, Kirsten; Hartmann, Jörg T.; Pink, Daniel; Schütte, Jochen; Ramadori, Giuliano; Hohenberger, Peter et al. (2012). "One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor". JAMA 307 (12): 1265–72. doi:10.1001/jama.2012.347. PMID 22453568.
- Demetri, George D.; von Mehren, Margaret; Blanke, Charles D.; Van Den Abbeele, Annick D.; Eisenberg, Burton; Roberts, Peter J.; Heinrich, Michael C.; Tuveson, David A. et al. (2002). "Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors". New England Journal of Medicine 347 (7): 472–80. doi:10.1056/NEJMoa020461. PMID 12181401.
- Verweij, Jaap; Casali, Paolo G; Zalcberg, John; Lecesne, Axel; Reichardt, Peter; Blay, Jean-Yves; Issels, Rolf; Van Oosterom, Allan et al. (2004). "Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial". The Lancet 364 (9440): 1127–34. doi:10.1016/S0140-6736(04)17098-0. PMID 15451219.
- Blanke, Charles D.; Rankin, Cathryn; Demetri, George D.; Ryan, Christopher W.; von Mehren, Margaret; Benjamin, Robert S.; Raymond, A. Kevin; Bramwell, Vivien H.C. et al. (2008). "Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate at Two Dose Levels in Patients with Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033". Journal of Clinical Oncology 26 (4): 626–32. doi:10.1200/JCO.2007.13.4452. PMID 18235122.
- Llovet, Josep M.; Ricci, Sergio; Mazzaferro, Vincenzo; Hilgard, Philip; Gane, Edward; Blanc, Jean-Frédéric; De Oliveira, Andre Cosme; Santoro, Armando et al. (2008). "Sorafenib in Advanced Hepatocellular Carcinoma". New England Journal of Medicine 359 (4): 378–90. doi:10.1056/NEJMoa0708857. PMID 18650514.