During the migration stage cells that are yet to become neurons begin to move up along the radial glia cells that provide scaffolding system for the cell migration. Cells along the radial glia cells generally move up vertically forming layered stuctures with predominantly radial migration patterns, including the cerebral cortex, the hippocampal formation, colliculi, and the cerebellar cortex. There are three groups of molecules that are crucial for migration:
1. Adhesion molecules
- adhesion molecules such as Reln, Astrotactin, Neuregulin, Integrins alpha 3,6, play a role in attaching the cells to the radial glia cell.
2. Microtubule binding proteins
- regulate stability of microtubles
3. Actin binding Molecules
- regulate protein to protein interactions. Examples are filamin1, Cdk5/p35