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Structural Biochemistry/Intranasal Route

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Intranasal drug administration is an attractive option for local and systemic delivery of many drugs. The nasal mucosa is – in other words, nose – easily accessible. Intranasal drug administration is noninvasive, almost painless and the most susceptible way of administrating drugs for children. Application can be performed easily by patients or by physicians in emergency settings. Intranasal drug delivery offers a rapid onset of therapeutic effects (local or systemic). Nasal application circumvents gastrointestinal degradation and hepatic first-pass metabolism of the drug. The drug, the vehicle and the application device form an undividable triad. Its selection is there- fore essential for the successful development of effec- tive nasal products. This paper discusses the feasibility and potential of intranasal administration. However, there are still many debatable topics on the following topics:

  1. the intended use (therapeutic considerations)
  2. the drug
  3. the vehicle
  4. the application device

Reference

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http://content.karger.com/ProdukteDB/Katalogteile/isbn3_8055/_96/_15/CUPDE40_04.pdf

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