Structural Biochemistry/Cell Signaling Pathways/Paracrine Signaling

General Information

Like "para" which means near, paracrine signaling is a form of cell signaling in which the target cell is near or adjacent to the signal-releasing cell while autocrine signaling acts on surface receptors on the same cell that produced the signal.

Paracrine is the secretion of a hormone by an organ other than an endocrine gland.

Below is a figure of the Oncogenic Ras of the paracrine signaling that promotes the growth of tumor.

File:Paracrine signaling.gif Oncogenic Ras promotes the transcription of cytokine genes (the double helix), leading to elevated levels of secreted cytokines (the blue spheres) that act to modulate the immune system (yellow cells), promoting angiogenesis (purple capillaries), activating tumor stroma, the brown cells.

Other Uses

Paracrine signaling is used in the signaling through the epithelial estrogen receptor which allows for proliferation and morphogenesis in the mammary gland. Estradiol is a major regulator of postnatal mammary gland development. It uses paracrine signaling to exert its effects through the estrogen receptor and is expressed in the mammary gland stroma and epithelium. Estradiol stimulates the secretion of prolactin by the pituitary gland and suppresses the secretion of other hormones called gonadotropins. These facts help understand that impairment of mammary gland development may be due to the mammary glands inability to react to the estradiol itself.. The signaling failure is usually a result of inactivation of the ER alpha (estrogen receptor alpha).

More conclusive tests will be needed in order to more clearly understand the mechanism behind this process, but it is clear that the ER alpha expression in the epithelium is a heterogenous process that involves using ductal cells which are triggered by estradiol processes. The ER alpha cells proliferate and act on a subtype of cells which releases paracrine signals that permit other epithelial cells to participate in growth.

Two paracrine signaling agents are growth factor and clotting factors. Growth factor signalling affects the development of tissues. An example is in insects where Allotostatin controls growth through paracrine action on the corpora allata.

In mature organisms, paracrine signaling is involved with allergen responses, tissue repair, formation of scar tissue, and blood clotting.

References

http://molinterv.aspetjournals.org/cgi/figsearch?fulltext=secreted&resourcetype=3

Paracrine Signaling with the ER Alpha-Sonia Mallepell, Sndree Krust, Pierre Chambon, Cathrin Brisken

Estrogen Target and SourceEndocr. Rev. 2006 27:677-706-U. Ohnemus, M. Uenalan, J. Inzunza, JA Gustafsson, R. Paus

Biology online (2009), viewed 15th of November 2014, http://www.biology-online.org/dictionary/Autocrine