Structural Biochemistry/Bioinformatics/Structural Alignments/Programs Used For Structural Alignment/SABERTOOTH

SABERTOOTH

SABERTOOTH uses structural profiles to perform structural alignments. The underlying structural profiles express the global connectivity of each residue. Although the vectorial representation is extremely condensed, this program recognizes the structural similarities with accuracy and quality comparable to established alignment tools based on coordinates. Also, the algorithm has favorable scaling of computation time with chain length. Since the algorithm is independent of the details of the structural representation, the framework can be generalized to sequence-to-sequence and sequence-to-structure comparisons within the same setup, and is therefore more general than other tools. SABERTOOTH can be accessed online via this website.