FIRE-SCLC (1994–2018) PMID 32496550 -- "Evaluation of first-line radiosurgery vs whole-brain radiotherapy for small cell lung cancer brain metastases: the FIRE-SCLC cohort study" (Rusthoven CG,JAMA Oncology. 2020, epub Jun 4)
Retrospective. 710 patients treated with first-line SRS without prior PCI or WBRT
On comparison with propensity-score matched dataset of first-line WBRT, WBRT was associated with improved time to CNS progression (HR, 0.38; P < .001), without an improvement in overall survival (median, 6.5 mo for SRS vs 5.2 mo for WBRT; P = .003)
Conclusion: "Results of this study suggest that the primary trade-offs associated with SRS without WBRT, including a shorter time to CNS progression without a decrease in overall survival, are similar to those observed in settings in which SRS is already established."
Review of SRS in SCLC: PMID: 32776807 -- "Radiosurgery for Small-Cell Brain Metastases: Challenging the Last Bastion of Preferential Whole-Brain Radiotherapy Delivery" (Journal of Clinical Oncology, epub August 2020)