Radiation Oncology/Drugs/Ethnopharmacologic therapeutic agent/Catharanthus roseus

  • Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle, is a species of flowering plant in the family Apocynaceae
  • It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer
  • The species has long been cultivated for herbal medicine
    • In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, though poisonous, are used against several diseases
    • In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma
  • Many of the vinca alkaloids were first isolated from Catharanthus roseus, including vinblastine and vincristine used in the treatment of leukemia and Hodgkin's lymphoma