Quizbowl science/Biology/Glucagon
Glucagon is a GPCR. It is released from the alpha cells of the Islets of Langerhans of the pancreas.[1]
Function edit
#Oh no! Glucose is gone!
Glucagon responds to low glucose levels. It acts on liver cells to increase blood glucose levels by:
- inhibiting glycolysis and
- activating gluconeogenesis
Mechanism edit
Protein Kinase A is activated. It:
- inhibits PFK-2 -- less F-2,6-BP made
- activates FBPase-2 -- more F-2,6-BP degraded
Results in lower F-2,6-BP:
- allosterically activates FBPase-1 -- increased gluconeogenesis (more glucose)
- less active PFK-1 -- decreased glycolysis
==Sources