ID Board Review/Immunocompromised Host

Primary Immunodeficiency

• Anatomic lesions
• Lymphocyte defects
• Combined immunodeficiency syndromes (including severe combined immunodeficiency [SCID])
• Phagocytes
• Complement deficiencies
• NK cell deficiencies

Hematologic Malignancies and Stem Cell Transplantation

• Infections associated with chemotherapy-induced neutropenia
• Stem cell transplant
• Syndromes
• Noninfectious conditions

Solid-organ Transplantation

• Donor-derived infections

• Surgical site infections

• Hospital-acquired infection

• Opportunistic infections

• Noninfectious conditions

Complications of immunosuppression in non-transplant population

This includes patients on disease-modifying agents, e.g. Tumor Necrosis Factor [TNF] blockers, Corticosteroids

• Bacteria

• Fungi

• Viruses

• Parasites

• Protozoa

Infection Prevention in the Immunosuppressed Host

• Immunizations

• Antimicrobials

• Environmental control