English: Genetic map of 15q11-q13 region. cen - centromere (constriction on a chromosome that separates the short [p] and the long [q] arms of a chromosome); tel – telomere (end of a chromosome). The jagged lines indicate the two common centromeric breakpoints and one telomeric breakpoint. The distance between a centromeric breakpoint and the telomeric breakpoint represents the deleted DNA in the common deletion. Circles in gray indicate genes implicated in Prader-Willi syndrome (PWS). The black circle represents the UBE3A – the disease gene in Angelman syndrome (AS). The white circles represent other genes. IC – imprinting center. (image from http://asclepius.com/angel/ube3a.htm)