The next and easiest sharp note to learn is C#. To play it, leave all of your fingers open. This note is frequently very sharp and hard to tune.
O O O - O O O
The D# (or E-Flat) appears in scales of the key of E. This is played by holding down all six of the left and right buttons and the first of the right hand lower keys with the little finger.
X X X - X X X
The A# (or B-Flat) is played by holding the top two left hand main keys as for an A natural and the lower of the right hand palm keys.