File:Signal transduction in sea-urchin sperm chemotaxis.jpg
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Summary
| Description |
English: A model of the signal-transduction pathway during chemotaxis of the sea urchin Arbacia punctulata. Binding of a chemoattractant (ligand) to the receptor — a membrane-bound guanylyl cyclase (GC) — activates the synthesis of cGMP from GTP. Cyclic GMP possibly opens cyclic nucleotide-gated (CNG) K+-selective channels, thereby causing hyperpolarization of the membrane. The cGMP signal is terminated by the hydrolysis of cGMP through phosphodiesterase (PDE) activity and inactivation of GC. On hyperpolarization, hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels allow the influx of Na+ that leads to depolarization and thereby causes a rapid Ca2+ entry through voltage-activated Ca2+ channels (Cav), Ca2+ ions interact by unknown mechanisms with the axoneme of the flagellum and cause an increase of the asymmetry of flagellar beat and eventually a turn or bend in the swimming trajectory. Ca2+ is removed from the flagellum by a Na+/Ca2+ exchange mechanism. [Taken from (Kaupp et al., 2006).] |
| Date | |
| Source | ftp://ftp.weizmann.ac.il/incoming/Fig.1.jpg |
| Author | Prof. Dr. U.B. Kaupp |
| Permission (Reusing this file) |
ftp://ftp.weizmann.ac.il/incoming/License_for_Fig1.pdf |
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Licensing
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
Attribution: Prof. Dr. U.B. Kaupp
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File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:09, 6 April 2013 | | 2,006 × 772 (498 KB) | Manfre87 | Reverted to version as of 23:08, 25 March 2009 |
| 14:05, 6 April 2013 |  | 2,006 × 772 (245 KB) | Manfre87 | Italian traduction; traduzione in italiano | |
| 23:08, 25 March 2009 |  | 2,006 × 772 (498 KB) | Graeme Bartlett | {{Information |Description={{en|1=Signal transduction in sea-urchin sperm chemotaxis, illustrating a cell membrane with embedded functions}} |Source=ftp://ftp.weizmann.ac.il/incoming/Fig.1.jpg |Author=Prof. Dr. U.B. Kaupp |Date=2006 |Permission=ftp://ftp. |
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